Development of an HDV Identification Algorithm
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Development of an HDV Identification Algorithm

Development and External Validation of an Algorithm for Identifying HDV RNA positive Patients

Background and Aims:
Accurate detection and treatment of HDV-infected patients can reduce disease-related morbidity and mortality. This study developed and validated real-world evidence-based algorithms to detect RNA-positive HDV patients from administrative claims data.

Methods:
This retrospective observational study identified HBV and HDV patients from laboratory testing data linked to administrative claims (HealthVerity; 2015–2022), with external validation performed using electronic health records (TriNetX; 2005–2023). Both diagnosis-based and machine-learning algorithms were evaluated. Performance metrics included area under the receiver operating characteristic curve (AUROC), area under precision-recall curve, sensitivity, specificity, positive predictive value (PPV), and accuracy. Internal validation results showed that diagnosis code-based algorithms identified HDV RNA-positivity with ≥88% accuracy.

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